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[小细胞支气管癌中一种特殊形式的巴泽克斯肢端角化病]

[A special form of Bazex acrokeratosis in small cell bronchial cancer].

作者信息

Hoepffner N, Albrecht H P, Haagen G, Diepgen T L, Hornstein O P

机构信息

Dermatologische Klinik mit Poliklinik, Universität Erlangen-Nürnberg.

出版信息

Hautarzt. 1992 Aug;43(8):496-9.

PMID:1324232
Abstract

A 66-year-old pensioner developed distinct, erythematosquamous and keratonic lesions on the hands and feet within 2 months, and also a progressive red-bluish discoloration of the whole integument. Clinical and X-ray exploration revealed a still asymptomatic small-cell bronchial carcinoma, so that the otherwise inexplicable skin lesions made an acrokeratotic paraneoplastic syndrome of the Bazex type seem most likely. This very rare syndrome has hitherto been observed only in patients with carcinomas of either the bronchial or the upper digestive tract, with or without cervical and mediastinal lymph node metastases. We report on our third patient with Bazex-type acrokeratosis, mainly because of the uncommon distribution and severity of his otherwise typical lesions. In addition, recent reports on this syndrome in the literature are reviewed.

摘要

一名66岁的退休人员在两个月内双手和双脚出现了明显的红斑鳞屑性和角化性病变,同时全身皮肤逐渐出现红蓝色变色。临床和X线检查发现了一个仍无症状的小细胞支气管癌,因此,原本无法解释的皮肤病变最有可能是巴泽克斯型肢端角化性副肿瘤综合征。这种非常罕见的综合征迄今为止仅在患有支气管癌或上消化道癌的患者中观察到,有无颈部和纵隔淋巴结转移。我们报告了第三例巴泽克斯型肢端角化病患者,主要是因为他典型病变的分布和严重程度不常见。此外,还对文献中关于该综合征的最新报道进行了综述。

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