von Hintzenstern J, Kiesewetter F, Simon M, Schell H, Hornstein O P
Dermatologische Klinik mit Poliklinik, Universität Erlangen-Nürnberg.
Hautarzt. 1990 Sep;41(9):490-3.
A 62-year old quarryman developed distinct, erythematosquamous and keratotic lesions associated with subungual hyperkeratosis and nail detachment on all fingertips within 9 months. Subsequently, scaly erythema of the nose and of the auricles appeared. Clinically paraneoplastic acrokeratosis Bazex (APB) was diagnosed. Thorough endoscopic examination revealed an asymptomatic squamous cell carcinoma at the base of the tongue, which had already metastasized to the regional lymph nodes. Impressive regression of most of the relevant skin symptoms occurred during combined neck dissection and radiotherapy. A survey of recent reports on APB in the literature is given.
一名62岁的采石工人在9个月内，所有指尖出现了明显的红斑鳞屑性和角化性损害，并伴有甲下角化过度和指甲脱离。随后，鼻子和耳廓出现鳞屑性红斑。临床诊断为副肿瘤性肢端角化病（APB）。全面的内镜检查发现舌根部有一无症状的鳞状细胞癌，且已转移至区域淋巴结。在颈部淋巴结清扫术和放疗联合治疗期间，大部分相关皮肤症状出现了显著消退。本文对近期文献中关于APB的报道进行了综述。
