Krootila K, Uusitalo H, Palkama A
Department of Anatomy, University of Helsinki, Finland.
J Ocul Pharmacol. 1992 Summer;8(2):121-7. doi: 10.1089/jop.1992.8.121.
Calcitonin gene-related peptide (CGRP) is a neuropeptide localized in the ocular sensory nerves. It is responsible for most of the irritative changes in the rabbit eye in neurogenic inflammation, namely vasodilation in the anterior uvea, breakdown of the blood-aqueous barrier and increase in the intraocular pressure. In the present study, intracameral methysergide inhibited the CGRP-induced irritative changes in the rabbit eye. Provided that sufficient concentration of methysergide could be reached in the anterior chamber after topical application, it might be possible to use locally administered methysergide to limit different pathophysiological conditions in the eye in which CGRP is involved.
降钙素基因相关肽（CGRP）是一种位于眼感觉神经中的神经肽。它是兔眼神经源性炎症中大多数刺激性变化的原因，即前葡萄膜血管舒张、血-房水屏障破坏和眼压升高。在本研究中，前房内注射麦角新碱可抑制CGRP诱导的兔眼刺激性变化。如果局部应用后前房能达到足够浓度的麦角新碱，那么使用局部给药的麦角新碱来限制眼内涉及CGRP的不同病理生理状况可能是可行的。
