Krootila K, Uusitalo H, Palkama A
Department of Anatomy, University of Helsinki, Finland.
Curr Eye Res. 1988 Jul;7(7):695-703. doi: 10.3109/02713688809033199.
The effects of sensory nerve stimulation (topical neutral formaldehyde, 1%) and intracameral injection of calcitonin gene-related peptide (CGRP) on regional ocular blood flow, intraocular pressure (IOP), the blood-aqueous barrier, pupil size, and blood pressure were studied in the rabbit. Sensory nerve stimulation elicited a typical irritative response in the rabbit eye, with vasodilation in the ciliary body (from 128 +/- 31 to 363 +/- 105 mg/min, p less than 0.05) accompanied with a breakdown of the blood-aqueous barrier, rise in the IOP, and miosis. CGRP caused similar, but not identical, changes in the eye: vasodilation in the ciliary body (from 60 +/- 14 to 258 +/- 75 mg/min, p less than 0.05), breakdown of the blood-aqueous barrier and rise in the IOP, accompanied with systemic hypotension. Miosis was not observed after CGRP. In the present study, the vasodilatory action of CGRP on the rabbit eye has been shown. This makes our understanding of the mechanism of the ocular irritative response after sensory nerve stimulation more complete. Thus, CGRP through vasodilation disrupts the blood-aqueous barrier and raises the IOP. The more intense increase in the IOP after sensory nerve stimulation than after CGRP is probably caused by a CGRP-induced vasodilation and breakdown of the blood-aqueous barrier, enhanced by a miosis-induced pupillary block.
在兔眼中研究了感觉神经刺激（局部应用1%中性甲醛）和前房内注射降钙素基因相关肽（CGRP）对局部眼血流、眼压（IOP）、血-房水屏障、瞳孔大小和血压的影响。感觉神经刺激在兔眼中引发典型的刺激反应，睫状体血管舒张（从128±31增至363±105mg/min，p<0.05），同时伴有血-房水屏障破坏、眼压升高和瞳孔缩小。CGRP在眼中引起相似但不完全相同的变化：睫状体血管舒张（从60±14增至258±75mg/min，p<0.05）、血-房水屏障破坏和眼压升高，并伴有全身低血压。CGRP注射后未观察到瞳孔缩小。在本研究中，已证明CGRP对兔眼有血管舒张作用。这使我们对感觉神经刺激后眼刺激反应机制的理解更加完整。因此，CGRP通过血管舒张破坏血-房水屏障并升高眼压。感觉神经刺激后眼压升高比CGRP后更强烈，可能是由于CGRP诱导的血管舒张和血-房水屏障破坏，以及瞳孔缩小诱导的瞳孔阻滞增强所致。
