Lozano de León F, Iglesias C, Lucio-Villegas M E, Lozano M C, Corzo J E, Martín-Mazuelos E, García-Bragado F
Unidad de Enfermedades Infecciosas (Servicio de Medicina Interna), Hospital Universitario de Valme, Sevilla.
Med Clin (Barc). 1992 Jul 4;99(6):210-2.
The human herpesvirus-6 (HHV-6) may be a cofactor of infection by the human immunodeficiency virus type 1 (HIV-1). However, there are discrepancies with respect to the possible epidemiological relation between both viruses. The aim of the present study was to study the prevalence of infection by the HHV-6 in intravenous drug addicts (IVDA) with and without HIV-1 infection.
IgG antibodies vs HHV-6 (anti-HHV-6-IgG) were determined by indirect immunofluorescence in 100 IVDA (29 seronegative and 71 seropositive for HIV-1 of which 45 were in stage II and 26 in IV-C1 of CDC) as well as in 100 healthy subjects of a similar age (control group).
The prevalence of anti-HHV-6-IgG was much higher in the whole group of IVDA than in the control group and was equal in the IVDA with HIV-1 infection and in those patients without infection. There was no significant difference between the latter and the control group with the same being seen between the IVDA in different stages of HIV-1 infection.
The results of this study suggest the existence of an epidemiological relation between human herpes virus-6 (HHV-6) infection and human immunodeficiency virus -1 (HIV-1). However, infection by the HHV-6 has no relation with the evolutive degree of the HIV-1 infection nor with intravenous drug addiction.
人类疱疹病毒6型（HHV-6）可能是人类免疫缺陷病毒1型（HIV-1）感染的一个辅助因素。然而，关于这两种病毒之间可能存在的流行病学关系存在差异。本研究的目的是研究HHV-6在有和没有HIV-1感染的静脉注射吸毒者（IVDA）中的感染率。
通过间接免疫荧光法在100名IVDA（29名HIV-1血清阴性和71名血清阳性，其中45名处于疾病控制与预防中心（CDC）的II期，26名处于IV-C1期）以及100名年龄相仿的健康受试者（对照组）中检测抗HHV-6-IgG抗体。
IVDA全组中抗HHV-6-IgG的感染率远高于对照组，且在感染HIV-1的IVDA和未感染的患者中相同。后者与对照组之间无显著差异，在HIV-1感染不同阶段的IVDA之间也观察到相同情况。
本研究结果提示人类疱疹病毒6型（HHV-6）感染与人类免疫缺陷病毒1型（HIV-1）之间存在流行病学关系。然而，HHV-6感染与HIV-1感染的进展程度以及静脉注射吸毒均无关。
