Greenblatt R M, Jacobson L P, Levine A M, Melnick S, Anastos K, Cohen M, DeHovitz J, Young M A, Burns D, Miotti P, Koelle D M
University of California, San Francisco, Infectious Diseases Division, San Francisco, CA 94122, USA.
J Infect Dis. 2001 Apr 1;183(7):1130-4. doi: 10.1086/319270. Epub 2001 Mar 8.
Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who reported Kaposi's sarcoma had HHV-8 antibodies. Among HIV-positive women, HHV-8 infection was associated with use of crack, cocaine, or heroin (76% vs. 65%; P<.001), past syphilis (29% vs. 20%; P<.001), an injection drug-using male sex partner (61% vs. 53%; P=.014), black race (P=.010), and enrollment site (P=.015). In multivariate analysis, HIV infection, older age, past syphilis, black race, and enrollment site were independently associated with HHV-8 infection. In this cohort of North American women, HHV-8 infection was associated with HIV infection, drug use, and risky sexual behavior.
关于人类疱疹病毒8型（HHV - 8）在女性中的感染流行病学，人们了解甚少。对感染人类免疫缺陷病毒（HIV）的女性和高危未感染HIV的女性进行了一项关于HHV - 8感染的横断面研究。使用针对非诱导（潜伏）和诱导（裂解）HHV - 8抗原的血清学检测，在一个多地点队列的2483名参与者中检测感染情况。4.1%的女性对潜伏抗原呈反应性，12.0%的女性对诱导抗原呈反应性。报告患有卡波西肉瘤的8名女性中有7名具有HHV - 8抗体。在HIV阳性女性中，HHV - 8感染与使用强效可卡因、可卡因或海洛因（76%对65%；P<0.001）、既往梅毒（29%对20%；P<0.001）、有注射吸毒史的男性性伴侣（61%对53%；P = 0.014）、黑人种族（P = 0.010）以及入组地点（P = 0.015）相关。在多变量分析中，HIV感染、年龄较大、既往梅毒、黑人种族和入组地点与HHV - 8感染独立相关。在这个北美女性队列中，HHV - 8感染与HIV感染、吸毒和危险性行为相关。
