Nakamura Y, Komatsu N, Nakauchi H
Laboratory of Cell Growth and Differentiation, Tsukuba Life Science Center, Japan.
Science. 1992 Aug 21;257(5073):1138-41. doi: 10.1126/science.257.5073.1138.
A form of the human erythropoietin receptor (EPOR) was identified in which the cytoplasmic region is truncated by alternative splicing. The truncated form of the receptor (EPOR-T) is the most prevalent form of EPOR in early-stage erythroid progenitor cells, but the full-length EPOR (EPOR-F) becomes the most prevalent form in late-stage progenitors. EPOR-T can transduce a mitogenic signal. However, cells transfected with EPOR-T are more prone to programmed cell death than those expressing EPOR-F. EPOR-F may transduce a signal to prevent programmed cell death that is independent of the mitogenic signal, and alternative splicing of the EPOR gene may have an important role in erythropoiesis.
一种人类促红细胞生成素受体（EPOR）形式被鉴定出来，其胞质区域通过可变剪接被截短。受体的截短形式（EPOR-T）是早期红系祖细胞中最普遍的EPOR形式，但全长EPOR（EPOR-F）在晚期祖细胞中成为最普遍的形式。EPOR-T能转导有丝分裂信号。然而，用EPOR-T转染的细胞比表达EPOR-F的细胞更易发生程序性细胞死亡。EPOR-F可能转导一个独立于有丝分裂信号的防止程序性细胞死亡的信号，并且EPOR基因的可变剪接可能在红细胞生成中起重要作用。
