Rebuffat P, Malendowicz L K, Andreis P G, Meneghelli V, Kasprzak A, Nussdorfer G G
Department of Anatomy, University of Padua, Italy.
Histol Histopathol. 1992 Apr;7(2):183-8.
The effects of the prolonged infusion with interleukin-1 beta (IL-1 beta) (20 pM.kg-1.min-1) on the function and morphology of the isolated inner cells of the rat adrenal cortex were investigated. After 3 and 5 days of IL-1 beta infusion, the level of circulating ACTH was below the control level, while the plasma concentration of corticosterone was strikingly elevated. After 5 days of infusion, isolated inner adrenocortical cells showed an enhanced basal and ACTH-stimulated corticosterone secretion, and showed a conspicuous hypertrophy. The acute exposure to IL-1 beta 10(-6) M did not affect the secretory activity of dispersed cell from either control or IL-1 beta-infused rats. These findings indicate that the prolonged exposure to high levels of circulating IL-1 beta, like those occurring during chronic inflammatory diseases, is able to enhance the growth and steroidogenic (glucocorticoid) capacity of the rat inner adrenocortical zones. Moreover, they suggest that the mechanism underlying this adrenocorticotrophic effect of IL-1 beta does not involve either a stimulation of the hypophyseal ACTH release or a direct stimulatory effect of monokine on adrenocortical cells. It is suggested that IL-1 beta may activate an intra-adrenal paracrine regulatory mechanism.
研究了大鼠肾上腺皮质分离的内层细胞长时间输注白细胞介素 -1β（IL -1β）（20 pM·kg⁻¹·min⁻¹）对其功能和形态的影响。在输注IL -1β 3天和5天后，循环促肾上腺皮质激素（ACTH）水平低于对照水平，而皮质酮的血浆浓度显著升高。输注5天后，分离的肾上腺皮质内层细胞显示基础和ACTH刺激的皮质酮分泌增强，并出现明显肥大。急性暴露于10⁻⁶ M的IL -1β对来自对照或IL -1β输注大鼠的分散细胞的分泌活性没有影响。这些发现表明，长时间暴露于高水平的循环IL -1β，如慢性炎症疾病期间发生的情况，能够增强大鼠肾上腺皮质内层区域的生长和类固醇生成（糖皮质激素）能力。此外，它们表明IL -1β这种促肾上腺皮质营养作用的潜在机制既不涉及刺激垂体ACTH释放，也不涉及单核因子对肾上腺皮质细胞的直接刺激作用。有人提出IL -1β可能激活肾上腺内旁分泌调节机制。
