前列腺素E2（PGE2）对健康男性促肾上腺皮质激素释放激素（CRH）诱导的促肾上腺皮质激素（ACTH）释放的作用。
Role of prostaglandin E2 (PGE2) on the corticotropin-releasing hormone (CRH)-induced ACTH release in healthy men.
作者信息
Zacharieva S, Borissova A M, Andonova K, Stoeva I, Matrozov P
机构信息
Institute of Endocrinology and Gerontology, Medical Academy, Sofia, Bulgaria.
出版信息
Horm Metab Res. 1992 Jul;24(7):336-8. doi: 10.1055/s-2007-1003327.
PMID:1325403
Abstract
The effect of PGE2 on ACTH and cortisol responses to CRH was studied in 6 healthy men who received CRH i.v. during either saline or PGE2 infusions which were started 60 min. before testing. ACTH and cortisol responses to CRH were greater during PGE2 infusion compared to the control study. The results indicate that PGE2 positively modulates CRH-induced ACTH secretion.
摘要
在6名健康男性中研究了前列腺素E2（PGE2）对促肾上腺皮质激素（ACTH）和皮质醇对促肾上腺皮质激素释放激素（CRH）反应的影响。这些男性在测试前60分钟开始静脉输注生理盐水或PGE2的过程中接受静脉注射CRH。与对照研究相比，在输注PGE2期间，ACTH和皮质醇对CRH的反应更大。结果表明，PGE2对CRH诱导的ACTH分泌具有正向调节作用。
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