Indomethacin and meclofenamate do not alter ACTH and cortisol responses to corticotropin-releasing hormone (CRH) in normal subjects.

The responses of plasma ACTH and cortisol to CRH were studied in seven healthy subjects before and after three days treatment with indomethacin and meclofenamate. Both cyclooxygenase blockers elicited a reduction of plasma levels of stable metabolite of prostaglandin E2, but did not alter significantly ACTH and cortisol responses to CRH. The clinical implication of this study is that the short-term treatment with indomethacin and meclofenamate at the usual therapeutic doses does not alter release of ACTH and cortisol either under basal or stimulated condition.