de Simone G, Devereux R B, Camargo M J, Volpe M, Wallerson D C, Atlas S A, Laragh J H
Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021.
J Hypertens. 1992 Aug;10(8):725-32.
To evaluate differences in left ventricular structural changes related to different hemodynamic patterns.
One-kidney, one clip (1K1C; volume-dependent hypertension) rats were two-kidney, one clip (2K1C; high-resistance hypertension) to determine whether these two types of Goldblatt rats showed different types of left ventricular adaptation.
M-mode echocardiography was used to study 28 2K1C and 19 1K1C Wistar rats 8 weeks after surgery and 55 age-matched control animals.
Systolic blood pressure was equally high in the two models; the 1K1C rats had a larger left ventricular chamber and normal plasma renin activity (PRA), whereas in the 2K1C rats PRA was increased and the left ventricular chamber was normal. The atrial natriuretic factor was significantly increased only in the 2K1C rats and was related to PRA. The left ventricular mass index was increased in both models, but more in the 1K1C than the 2K1C rats.
In both models the degree of left ventricular hypertrophy was associated with the interacting effects of the hemodynamic component superimposed on the primary hemodynamic pattern (i.e. blood pressure as an expression of pressure overload in the primarily volume-dependent 1K1C rats and the left ventricular chamber size as an expression of volume overload in the high-resistance 2K1C rats). The interaction between pressure and volume increased the left ventricular wall thickness in both models, with additional chamber enlargement in the 1K1C rats. In these rats, the increase in left ventricular mass was more pronounced due to the greater volume load on the heart.
评估与不同血流动力学模式相关的左心室结构变化差异。
将单肾单夹（1K1C；容量依赖性高血压）大鼠转变为双肾单夹（2K1C；高阻力高血压）大鼠，以确定这两种类型的戈德布拉特大鼠是否表现出不同类型的左心室适应性变化。
采用M型超声心动图对28只术后8周的2K1C Wistar大鼠、19只术后8周的1K1C Wistar大鼠以及55只年龄匹配的对照动物进行研究。
两种模型的收缩压均同样升高；1K1C大鼠左心室腔较大且血浆肾素活性（PRA）正常，而2K1C大鼠的PRA升高且左心室腔正常。仅在2K1C大鼠中，心房利钠因子显著升高，且与PRA相关。两种模型的左心室质量指数均升高，但1K1C大鼠升高得比2K1C大鼠更多。
在两种模型中，左心室肥厚程度与叠加在主要血流动力学模式上的血流动力学成分的相互作用有关（即，在主要为容量依赖性的1K1C大鼠中，血压作为压力超负荷的一种表现；在高阻力的2K1C大鼠中，左心室腔大小作为容量超负荷的一种表现）。压力与容量之间的相互作用在两种模型中均增加了左心室壁厚度，1K1C大鼠还伴有额外的心室扩大。在这些大鼠中，由于心脏承受的容量负荷更大，左心室质量的增加更为明显。
