Martire M, Pistritto G
Istituto di Farmacologia, Facoltà di Medicina e Chirurgia, Università Cattolica del Sacro Cuore, Rome, Italy.
Pharmacol Res. 1992 Apr;25(3):203-15. doi: 10.1016/s1043-6618(05)80069-6.
Neuropeptide Y (NPY), first isolated in 1982, is widely distributed among the neurons of the central and peripheral nervous systems, often in close association with catecholamines. Because of its wide distribution and concentrations in selected areas of the brain, NPY is considered a putative neurotransmitter with several possible physiological effects including modulation of blood pressure, food intake and pituitary hormone release at a central level. Peripherally, the peptide seems to be involved, via direct and indirect mechanisms, in noradrenaline (NA)-mediated vasoconstriction. The ability of NPY to interact with the catecholamine transmission line may underly a possible modulatory influence of NPY on catecholamine receptor characteristics. We recently observed interaction between alpha-2 adrenergic receptors and those for NPY at the presynaptic level. Additional data from our studies in spontaneously hypertensive rats suggest that impairment of these interactions may contribute to the hypertension in this strain.
神经肽Y（NPY）于1982年首次分离出来，广泛分布于中枢神经系统和外周神经系统的神经元中，常与儿茶酚胺密切相关。由于其在大脑特定区域的广泛分布和浓度，NPY被认为是一种具有多种可能生理作用的假定神经递质，包括在中枢水平调节血压、食物摄入和垂体激素释放。在外周，该肽似乎通过直接和间接机制参与去甲肾上腺素（NA）介导的血管收缩。NPY与儿茶酚胺传递途径相互作用的能力可能是其对儿茶酚胺受体特性产生潜在调节作用的基础。我们最近观察到α-2肾上腺素能受体与NPY受体在突触前水平存在相互作用。我们对自发性高血压大鼠的研究所得的其他数据表明，这些相互作用的受损可能导致该品系大鼠患高血压。
