Tookey P A, Ades A E, Peckham C S
Epidemiology and Biostatistics Unit, Institute of Child Health, London.
Arch Dis Child. 1992 Jul;67(7 Spec No):779-83. doi: 10.1136/adc.67.7_spec_no.779.
Over 20,000 women attending for antenatal care at three London hospitals were prospectively studied to determine the prevalence of cytomegalovirus (CMV) antibodies; 54.4% of these women were CMV seropositive. Ethnic group was strongly associated with CMV status: 45.9% of white women were seropositive, 88.2% of Asian, and 77.2% of black women (African/Caribbean ethnic origin). Among 12,159 white women born in the British Isles, seropositivity was independently associated with increasing parity, older age, lower social class, and being single at antenatal booking. The findings are consistent with the hypothesis that, in the UK, child to mother transmission of infection plays a significant part in the acquisition of CMV infection in adult life.
对伦敦三家医院超过20000名接受产前护理的女性进行了前瞻性研究，以确定巨细胞病毒（CMV）抗体的流行情况；这些女性中有54.4%为CMV血清阳性。种族与CMV感染状况密切相关：45.9%的白人女性血清呈阳性，88.2%的亚洲女性以及77.2%的黑人女性（非洲/加勒比海裔）血清呈阳性。在12159名出生于不列颠群岛的白人女性中，血清阳性与产次增加、年龄较大、社会阶层较低以及产前登记时单身独立相关。这些发现与以下假设一致：在英国，儿童到母亲的感染传播在成人期获得CMV感染中起着重要作用。
