Medical Laboratory Sciences, Hawassa University College of Medicine and Health Sciences, Hawassa, South Ethiopia, Ethiopia
Department of Diagnostic Sciences, Ghent University Faculty of Medicine and Health Sciences, Gent, Belgium.
BMJ Open. 2021 Oct 21;11(10):e051390. doi: 10.1136/bmjopen-2021-051390.
The aim of this study was to assess the seroprevalence and associated factors of cytomegalovirus (CMV) among pregnant women in Southern Ethiopia.
Cross-sectional study.
The study was conducted in Hawassa University comprehensive and specialised hospital. Hawassa, Southern Ethiopia.
A total of 600 consecutive pregnant women attending the delivery ward were recruited for the study from August to October 2020.
The study assessed the rate of maternal anti-CMV IgG and IgM antibodies. The association of obstetric history, sociodemographic and behavioural characteristics with seropositivity of CMV was also evaluated based on the collected data using structured questioners.
Seropositivity for CMV IgM antibodies was 8.2% (49/600) (95% CI 6% to 10.5%), whereas the CMV IgG was 88.7% (532/600), (95% CI 89.5% to 94.0%). Seroprevalence of CMV IgM was higher in women of older age, currently unmarried, having nursery schooled children and with any of the detected curable sexually transmitted infections, while seroprevalence of CMV IgG was significantly associated only with women having nursery schooled children. Seroprevalence was not significantly associated with previous adverse pregnancy outcome, gravidity, being a child daycare occupant mother and newborn birth weight.
In the present study, we identified a high rate of CMV IgM and CMV IgG seroprevalence among pregnant women in Southern Ethiopia. Given that there is no existing CMV diagnosis, special attention should be designed to pregnant women in parallel to the existing antenatal care facility. Besides, training healthcare professionals will support awareness conception among pregnant women concerning the sequels of CMV infection during pregnancy.
本研究旨在评估埃塞俄比亚南部孕妇巨细胞病毒（CMV）的血清流行率及其相关因素。
横断面研究。
本研究在 Hawassa 大学综合和专科医院进行。Hawassa，埃塞俄比亚南部。
2020 年 8 月至 10 月，共有 600 名连续就诊于分娩病房的孕妇参与了这项研究。
本研究评估了母体抗 CMV IgG 和 IgM 抗体的发生率。根据收集到的数据，利用结构式问卷，还评估了产科史、社会人口统计学和行为特征与 CMV 血清阳性率的相关性。
CMV IgM 抗体的血清阳性率为 8.2%（49/600）（95%CI 6%至 10.5%），而 CMV IgG 为 88.7%（532/600）（95%CI 89.5%至 94.0%）。CMV IgM 的血清阳性率在年龄较大、目前未婚、有幼儿园儿童且有任何可治愈的性传播感染的女性中较高，而 CMV IgG 的血清阳性率仅与有幼儿园儿童的女性显著相关。CMV 的血清阳性率与既往不良妊娠结局、孕次、儿童日托母亲和新生儿出生体重无显著相关性。
在本研究中，我们发现埃塞俄比亚南部孕妇 CMV IgM 和 CMV IgG 的血清阳性率较高。鉴于目前尚无 CMV 诊断方法，除了现有的产前保健设施外，还应特别关注孕妇。此外，培训医疗保健专业人员将有助于提高孕妇对妊娠期间 CMV 感染后果的认识。
