Bartnitzke S, Motzko H, Rosenhagen C, Bullerdiek J
Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.
Cancer Genet Cytogenet. 1992 Aug;62(1):29-31. doi: 10.1016/0165-4608(92)90033-5.
We report a benign mixed tumor of the canine mammary gland which showed an r(X) and trisomy 5 as the only clonal karyotypic deviations. Clonal aberrations were observed in 79 of 160 of the metaphases. Of these, 48 cells had both the r(X) and trisomy 5, whereas the remaining metaphases were characterized by the r(X) as the only clonal aberration. We conclude that formation of the ring chromosome was the first abnormality, followed by trisomy 5 during the course of karyotypic evolution.
我们报告了一例犬乳腺良性混合瘤，其显示r(X)和5号染色体三体是唯一的克隆性核型异常。在160个中期相中，79个观察到克隆性畸变。其中，48个细胞同时存在r(X)和5号染色体三体，而其余中期相的特征是仅r(X)这一克隆性畸变。我们得出结论，在核型进化过程中，环状染色体的形成是首个异常，随后出现了5号染色体三体。
