松果体肾上腺素能——环磷酸鸟苷反应在肾上腺素能——环磷酸腺苷反应两周后出现。

The pineal adrenergic----cyclic GMP response develops two weeks after the adrenergic----cyclic AMP response.

作者信息

Weller J L, Klein D C

机构信息

Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.

出版信息

Brain Res Dev Brain Res. 1992 Jul 24;68(1):144-7. doi: 10.1016/0165-3806(92)90258-x.

DOI:10.1016/0165-3806(92)90258-x

PMID:1325876

Abstract

Pineal metabolism is regulated primarily by noradrenergic innervation. Stimulation of the adult gland with norepinephrine elevates both cyclic AMP and cyclic GMP production, through remarkably similar mechanisms requiring activation of both beta- and alpha 1-adrenergic receptors. As described here, however, the adrenergic stimulation of cyclic GMP is first detectable about 2 weeks after the cyclic AMP response can be detected. This indicates there is a profound difference in when cyclic AMP- and cyclic GMP-regulated processes can be adrenergically regulated.

摘要

松果体代谢主要由去甲肾上腺素能神经支配调节。用去甲肾上腺素刺激成年腺体可通过需要激活β-和α1-肾上腺素能受体的非常相似的机制提高环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的产生。然而，如此处所述，cGMP的肾上腺素能刺激在可检测到cAMP反应后约2周首次被检测到。这表明cAMP和cGMP调节的过程在何时可被肾上腺素能调节方面存在深刻差异。