膦甲酸钠与更昔洛韦治疗艾滋病患者巨细胞病毒性视网膜炎的随机对照研究

Foscarnet and Ganciclovir in the treatment of CMV retinitis in AIDS patients: a randomised comparison.

作者信息

Moyle G, Harman C, Mitchell S, Mathalone B, Gazzard B G

机构信息

HIV/GUM Unit, Kobler Centre, London, U.K.

出版信息

J Infect. 1992 Jul;25(1):21-7. doi: 10.1016/0163-4453(92)93417-o.

DOI:10.1016/0163-4453(92)93417-o

PMID:1326012

Abstract

Ganciclovir and Foscarnet were compared in an open randomised trial as treatment and secondary prophylaxis of cytomegalovirus (CMV) retinitis in patients with AIDS. Patients responded more rapidly to Ganciclovir than to Foscarnet although eventual response rates were similar with both drugs. During maintenance therapy there were trends towards more delayed reactivation of CMV and fewer adverse events requiring changes in therapy, in the Ganciclovir group. However, these patients had more line infections and a higher blood transfusion requirement.

摘要

在一项开放性随机试验中，对更昔洛韦和膦甲酸钠进行了比较，以评估它们对艾滋病患者巨细胞病毒（CMV）视网膜炎的治疗效果和二级预防作用。患者对更昔洛韦的反应比对膦甲酸钠更快，尽管两种药物最终的有效率相似。在维持治疗期间，更昔洛韦组的CMV再激活出现延迟的趋势更明显，因不良事件而需要改变治疗方案的情况也更少。然而，这些患者有更多的静脉感染，输血需求也更高。