Rodiukova E N, Kharitonova K I, Stupak I N, Stupak V V
Zh Vopr Neirokhir Im N N Burdenko. 1992 Mar-Jun(2-3):12-5.
The authors examined patients with penetrating cerebrocranial trauma (CCT) and uneventful course of traumatic disease (30) and those with CCT complicated by intracranial purulent process (24 persons). A direct correlation of the marked character and severity of the clinical course of the posttraumatic period and the changes in the immune system was revealed. Increase of the level of neutrophil rosette formation, indices of the NST test, the activity and intensity of neutrophil phagocytosis in penetrating CCT allows the development of an intracranial purulent process to be predicted at an early stage before the appearance of clinical sings. Decrease of the number of spontaneous rosette-forming and formazan-positive neutrophils is an indication of an unfavourable course of an intracranial purulent complication with a fatal outcome.
作者检查了穿透性颅脑创伤（CCT）且创伤性疾病病程平稳的患者（30例）以及并发颅内化脓性病变的CCT患者（24例）。结果显示，创伤后时期临床病程的显著特征和严重程度与免疫系统变化之间存在直接关联。穿透性CCT患者中性粒细胞玫瑰花结形成水平、NST试验指标、中性粒细胞吞噬活性和强度的升高，能够在临床症状出现之前的早期阶段预测颅内化脓性病变的发展。自发性玫瑰花结形成中性粒细胞和甲臜阳性中性粒细胞数量的减少表明颅内化脓性并发症预后不良，可能导致致命后果。
