Honda Z, Nakamura M, Seyama Y, Shimizu T
Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan.
J Lipid Mediat. 1992 Jun-Jul;5(2):105-7.
Platelet-activating factor (PAF) is a naturally occurring phospholipid possessing proinflammatory and shock-inducing activities. Although PAF exerts these functions via specific receptors, the molecular structures of the receptor has not been clarified. We have isolated a cDNA coding for PAF receptor through expression cloning. The PAF receptor expressed in Xenopus laevis oocytes and COS-7 cells showed pharmacological properties consistent with those in previous reports. Sequence analysis revealed that PAF receptor belongs to the superfamily of G-protein-coupled receptors.
血小板活化因子（PAF）是一种天然存在的磷脂，具有促炎和诱导休克的活性。尽管PAF通过特定受体发挥这些功能，但其受体的分子结构尚未阐明。我们通过表达克隆分离出了编码PAF受体的cDNA。在非洲爪蟾卵母细胞和COS-7细胞中表达的PAF受体表现出与先前报道一致的药理学特性。序列分析表明，PAF受体属于G蛋白偶联受体超家族。
