醋酸脱氧皮质酮和16β-羟基脱氢表雄酮对大鼠血压及血浆肾素活性的影响。
Effect of deoxycorticosterone acetate and 16beta-hydroxy-dehydroepiandrosterone on blood pressure and plasma renin activity of rats.
作者信息
Ayachi S, Hall C E, Holland O B, Gomez-Sanchez C
出版信息
Proc Soc Exp Biol Med. 1976 Jun;152(2):218-20. doi: 10.3181/00379727-152-39364.
PMID:132667
Abstract
Intact female Sprague-Dawley rats were given daily injections of either 3.125 mg of deoxycorticosterone or 5.0 mg of 16beta-hydroxy-dehydroepiandrosterone, calculated from the activities reported for each to be equivalent mineralocorticoid dosages. The former caused hypertension, cardiorenal enlargement, increased urine output and depressed PRA. Treatment with 16beta-OH-DHEA had no such effect, raising questions regarding its classification as a mineralocorticoid.
摘要
给成年雌性斯普拉格-道利大鼠每日注射3.125毫克脱氧皮质酮或5.0毫克16β-羟基脱氢表雄酮，根据报道的每种药物的活性计算，二者具有等效的盐皮质激素剂量。前者导致高血压、心肾增大、尿量增加和血浆肾素活性降低。用16β-羟基脱氢表雄酮治疗则没有这种效果，这引发了关于将其归类为盐皮质激素的质疑。
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