关于16β-羟基脱氢表雄酮的盐皮质激素和致高血压特性
On the mineralocorticoid and hypertensogenic properties of 16beta-hydroxy-dehydroepiandrosterone.
作者信息
Gomez-Sanchez C, Holland O B, Hall C E, Ayachi S
出版信息
Experientia. 1976 Aug 15;32(8):1067-9. doi: 10.1007/BF01933976.
PMID:182526
Abstract
Dosages of either 1 or 2 mg daily of 16beta-hydroxy-dehydroepiandrosterone, given to mononephrectomized, salt-loaded female rats, had no detectable effect upon saline consumption, blood pressure, kallikrein excretion or heart and kidney weight. Its alleged mineralocorticoid properties, as judged by these criteria, were not demonstrable.
摘要
给单侧肾切除、盐负荷的雌性大鼠每日服用1毫克或2毫克的16β-羟基脱氢表雄酮，对其盐水摄入量、血压、激肽释放酶排泄或心脏和肾脏重量均未产生可检测到的影响。根据这些标准判断，其所谓的盐皮质激素特性并未得到证实。
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