Batra S, Alenfall J
Kabi Pharmacia Oncology, Lund, Sweden.
Life Sci. 1992;51(15):1211-5. doi: 10.1016/0024-3205(92)90358-v.
The effect of orchiectomy on peripheral benzodiazepine receptors (PBZr) in the rabbit prostate was studied. The mean PBZr density in the mitochondrial fraction isolated from prostates of intact (non castrated) rabbits was 4066 fmol/mg protein which following castration increased to 7236 fmol/mg protein (p less than 0.005). The apparent dissociation constant (KD) of prostatic PBZr was higher in castrated rabbits (4.2 nM) than in intact animals (2.7 nM). These data suggest a role of androgen in the regulation of prostatic PBZr.
研究了去势对兔前列腺外周苯二氮䓬受体（PBZr）的影响。从完整（未阉割）兔前列腺分离的线粒体组分中，PBZr的平均密度为4066 fmol/mg蛋白质，去势后增加到7236 fmol/mg蛋白质（p<0.005）。去势兔前列腺PBZr的表观解离常数（KD）（4.2 nM）高于完整动物（2.7 nM）。这些数据表明雄激素在前列腺PBZr的调节中起作用。
