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睾酮对邓宁G前列腺腺癌外周苯二氮䓬受体密度的调节作用

Modulation of peripheral benzodiazepine receptor density by testosterone in Dunning G prostatic adenocarcinoma.

作者信息

Alenfall J, Batra S

机构信息

Department of Pharmacology, University of Lund, Sweden.

出版信息

Life Sci. 1995;56(22):1897-902. doi: 10.1016/0024-3205(95)00164-2.

DOI:10.1016/0024-3205(95)00164-2
PMID:7746098
Abstract

Effect of orchiectomy on peripheral benzodiazepine receptors (PBZr) density in hormone sensitive, poorly differentiated Dunning G rat prostatic tumors were studied. A significant increase in PBZr density (1.4-fold) was observed in both mitochondrial fractions (m-fractions) and microsomal fractions (p-fractions) of tumors from orchiectomized rats as compared to tumors from sham operated controls. Substitution with testosterone in orchiectomized rats repressed the PBZr density in both m- and p-fractions to that of the control animals. The data strongly suggest a regulatory role of testosterone on the PBZr density in these hormone sensitive prostatic tumors.

摘要

研究了去势对激素敏感、低分化的邓宁G大鼠前列腺肿瘤外周苯二氮䓬受体（PBZr）密度的影响。与假手术对照组的肿瘤相比，去势大鼠肿瘤的线粒体部分（m部分）和微粒体部分（p部分）的PBZr密度均显著增加（1.4倍）。去势大鼠用睾酮替代后，m部分和p部分的PBZr密度均降至对照动物的水平。这些数据有力地表明睾酮对这些激素敏感前列腺肿瘤中的PBZr密度具有调节作用。

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Modulation of peripheral benzodiazepine receptor density by testosterone in Dunning G prostatic adenocarcinoma.睾酮对邓宁G前列腺腺癌外周苯二氮䓬受体密度的调节作用
Life Sci. 1995;56(22):1897-902. doi: 10.1016/0024-3205(95)00164-2.
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