Flückiger A, Schlup P
Medizinische Abteilung, Spital Grenchen.
Schweiz Med Wochenschr. 1992 Aug 15;122(33):1221-3.
A patient with metastatic VIP-producing pancreatic tumor was successfully treated with subcutaneous octreotide, an analogue of somatostatin, for more than 4 years. The profuse diarrhea was rapidly controlled and the plasma concentrations of the hormones (VIP, neurotensin, gastrin, pancreatic polypeptide) fell to nearly normal within 2 months. Because of asymptomatic increase in tumor size, we added chemotherapy 2 years later. Since the drug is rapidly effective and well tolerated, it will probably become the therapy of choice in this syndrome.
一名患有分泌血管活性肠肽（VIP）的转移性胰腺肿瘤患者，接受皮下注射生长抑素类似物奥曲肽成功治疗超过4年。大量腹泻迅速得到控制，血浆中多种激素（血管活性肠肽、神经降压素、胃泌素、胰多肽）的浓度在2个月内降至接近正常水平。由于肿瘤大小出现无症状性增加，2年后我们加用了化疗。鉴于该药物起效迅速且耐受性良好，它可能会成为这种综合征的首选治疗方法。
