Shimizu J, Kanai T, Monden M, Sakon M, Gotoh M, Umeshita K, Tarui T, Monden T, Mori T, Tomoda K
Dept. of Surgery II, Osaka University Medical School.
Gan To Kagaku Ryoho. 1992 Aug;19(10 Suppl):1437-40.
The efficacy of transarterial immuno-embolization therapy (TIE) was investigated in 7 patients with multiple hepatocellular carcinoma (HCC). We administered OK-432 (10 KE), fibrinogen (30 mg/ml) and thrombin (1 U/ml) as a new treatment for HCC with intrahepatic metastasis. In all patients with a high level of AFP, the AFP level decreased promptly less than the pretreatment level after TIE therapy. High fever in all cases, epigastralgia in 6 cases and appetite loss in 3 cases were observed after TIE therapy. Our results indicate that this therapy may be a safe and effective method in HCC patients with intrahepatic metastasis.
对7例多发性肝细胞癌（HCC）患者进行了经动脉免疫栓塞治疗（TIE）的疗效研究。我们给予OK-432（10KE）、纤维蛋白原（30mg/ml）和凝血酶（1U/ml）作为治疗肝内转移HCC的新方法。在所有甲胎蛋白（AFP）水平高的患者中，TIE治疗后AFP水平迅速降至低于治疗前水平。TIE治疗后，所有病例均出现高热，6例出现上腹部疼痛，3例出现食欲减退。我们的结果表明，这种治疗方法对于肝内转移的HCC患者可能是一种安全有效的方法。
