Eguchi H, Takeda T, Sakon M, Umeshita K, Ohzato H, Dono K, Gotoh M, Monden T, Monden M
Dept. of Surgery 2, Osaka University Medical School.
Gan To Kagaku Ryoho. 1997 Sep;24(12):1665-7.
Surgical resection, transcatheter arterial embolization (TAE) and percutaneous ethanol injection therapy (PEIT) are effective for hepatocellular carcinoma (HCC), but the recurrence rate is high. We have devised a new therapy of transarterial immuno-embolization (TIE) with OK-432, fibrinogen and thrombin, and 2 cases are reported. Case 1: A 78-year-old Japanese male with HCC (diameter, 4 cm in subsegment 5) received TIE. The tumor size was markedly decreased, and the patient survived for more than 3 years without recurrence. Case 2: A 61-year-old Japanese male with HCC (diameter, 4.5 cm in segment 5) received hepatic subsegmentectomy following TIE. Histological examination of resected specimens following TIE showed massive infiltration of mononuclear cells in the main tumor. Tumor recurrence had developed three times thereafter, but was effectively treated by TIE. TIE may be an effective therapy for HCC.
手术切除、经导管动脉栓塞术（TAE）和经皮乙醇注射疗法（PEIT）对肝细胞癌（HCC）有效，但复发率高。我们设计了一种用OK-432、纤维蛋白原和凝血酶进行经动脉免疫栓塞（TIE）的新疗法，并报告2例病例。病例1：一名78岁日本男性肝细胞癌患者（肿瘤位于5段亚段，直径4 cm）接受了TIE治疗。肿瘤大小明显缩小，患者存活超过3年无复发。病例2：一名61岁日本男性肝细胞癌患者（肿瘤位于5段，直径4.5 cm）在TIE后接受了肝亚段切除术。TIE后切除标本的组织学检查显示主肿瘤中有大量单核细胞浸润。此后肿瘤复发3次，但通过TIE得到有效治疗。TIE可能是治疗肝细胞癌的一种有效疗法。
