Dowling S, Fischer J J, Rockwell S
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT.
Biomater Artif Cells Immobilization Biotechnol. 1992;20(2-4):903-5. doi: 10.3109/10731199209119738.
Several clinical trials have been reported using Fluosol and oxygen breathing as an adjunct to radiation. Theoretical considerations and animal experiments, however, indicate that a combination of perfluorochemicals and hyperbaric oxygen (HBO) increases tumor oxygenation and radiation response to a greater extent than is seen either with a perfluorochemical and normobaric oxygen or with HBO alone. This is the first report of a pilot study of the use of Fluosol and HBO with radiation in humans. Twenty patients with anaplastic astrocytoma or glioblastoma multiforme were treated in a phase I trial of radiation with Fluosol and HBO at three atmospheres. Total Fluosol dose was escalated from 42 ml/kg in six courses to 80 ml/kg in four courses. Patients were irradiated in an HBO chamber with 600 cGy weekly fractions following Fluosol administration. Sixteen patients completed treatment; no interruption was necessitated by treatment toxicity. The addition of Fluosol/HBO did not increase the incidence of HBO related toxicities. No significant chronic toxicities were seen. This pilot study demonstrates that Fluosol and HBO can safely be used as an adjunct to radiation in the treatment of human tumors.
已有多项关于使用氟碳乳剂和吸氧作为放疗辅助手段的临床试验报告。然而，理论思考和动物实验表明，全氟化合物与高压氧（HBO）联合使用比单独使用全氟化合物和常压氧或单独使用HBO能更大程度地提高肿瘤氧合作用及放疗反应。这是关于在人体中使用氟碳乳剂和HBO联合放疗的初步研究的首篇报告。20例间变性星形细胞瘤或多形性胶质母细胞瘤患者在一项I期试验中接受了在三个大气压下使用氟碳乳剂和HBO的放疗。氟碳乳剂的总剂量从六个疗程的42毫升/千克逐步增加到四个疗程的80毫升/千克。在给予氟碳乳剂后，患者在HBO舱内每周接受600厘戈瑞分次照射。16例患者完成了治疗；未因治疗毒性而中断治疗。添加氟碳乳剂/HBO并未增加与HBO相关的毒性发生率。未观察到明显的慢性毒性。这项初步研究表明氟碳乳剂和HBO可安全地用作治疗人类肿瘤放疗的辅助手段。
