Mudraia I S, Kirpatovskiĭ V I
Biull Eksp Biol Med. 1992 Apr;113(4):363-5.
Investigations on the isolated pieces from upper part of human ureters and upper and lower parts of dog ureters were performed. Isometric contractions during electrical stimulation in Lock solution (37 degrees C) and their changes after adrenomimetic drug and adrenoblocking drug perfusion were studied. The pieces of human ureters had more average weight and rest tension, but less isometric tension during rhythmic electrical stimulation and more pronounced hypersodium contracture in contrast to dog ureters. Adrenaline and noradrenaline augmented contractions of human and dog ureters. Isadrin increased the contractility of the upper parts of human ureters and the lower parts of dog ureters, but decreased--the upper segments of dog ureters. Adrenoblocking agents modified the action of adrenomimetics. After blockade of alpha-receptors by phentolamine, isadrin decreased the contractions of all studied pieces of ureters, however, adrenaline decreased contractility of human ureters but increased--dog ureters. It may be proposed, that there are alpha 1 and alpha 2 receptors, that stimulated the contractility of human and dog ureters, beta 1 adrenoreceptors, that inhibited the contractions during blockade of alpha-receptors, and beta 2-receptors, that in these conditions increased the contractions of dog ureter but decreased the contractions of human ureters.
对人体输尿管上段以及犬输尿管上、下段的离体组织进行了研究。研究了在Lock溶液（37℃）中电刺激时的等长收缩情况，以及在灌注拟肾上腺素药和肾上腺素能阻断药后等长收缩的变化。与犬输尿管相比，人体输尿管组织平均重量和静息张力更大，但在节律性电刺激时等长张力较小，且高钠挛缩更明显。肾上腺素和去甲肾上腺素增强了人体和犬输尿管的收缩。异丙肾上腺素增加了人体输尿管上段和犬输尿管下段的收缩力，但降低了犬输尿管上段的收缩力。肾上腺素能阻断剂改变了拟肾上腺素药的作用。在用酚妥拉明阻断α受体后，异丙肾上腺素降低了所有研究的输尿管组织的收缩力，然而，肾上腺素降低了人体输尿管的收缩力，但增加了犬输尿管的收缩力。可以推测，存在刺激人体和犬输尿管收缩力的α1和α2受体、在α受体阻断期间抑制收缩的β1肾上腺素能受体，以及在这些情况下增加犬输尿管收缩力但降低人体输尿管收缩力的β2受体。
