Weiss R M, Bassett A L, Hoffman B F
Invest Urol. 1978 Sep;16(2):123-7.
To determine whether the ureter is innervated by the autonomic nervous system, isolated canine ureters were superfused with modified Tyrode solution, and force developed in response to 100-msec duration stimuli at a rate of 3 per min was monitored. Norepinephrine and phenylephrine significantly increased developed force; the latter more than the former. These increases in developed force were blocked by phentolamine, and propranolol enhanced the stimulatory effect of norepinephrine. In the presence of phentolamine, norepinephrine significantly decreased developed force. Isoproterenol significantly decreased developed force and this significant decrease in contractility was not observed in the presence of propranolol. High intensity, high frequency, short duration stimuli which in themselves were unable to excite quiescent rabbit and canine ureteral segments potentiated contractile force of segments contracting at the basal rate of 3 per min in response to long duration stimuli. When these same high intensity, high frequency, short duration stimuli were applied to ureteral segments pretreated with phentolamine, the developed force of the basally driven preparations decreased. These data suggest the presence of alpha-stimulatory and beta-inhibitory adrenergic receptors in canine and rabbit ureter and provide evidence for adrenergic tissue within the wall of the ureter that can influence contractile force.
为了确定输尿管是否受自主神经系统支配，将离体犬输尿管用改良的台氏液进行灌流，并监测其对以每分钟3次的频率施加的持续100毫秒的刺激产生的张力。去甲肾上腺素和苯肾上腺素显著增加所产生的张力；后者的作用强于前者。这些所产生张力的增加被酚妥拉明阻断，而普萘洛尔增强了去甲肾上腺素的刺激作用。在酚妥拉明存在的情况下，去甲肾上腺素显著降低所产生的张力。异丙肾上腺素显著降低所产生的张力，而在普萘洛尔存在的情况下未观察到这种收缩性的显著降低。本身无法激发静息兔和犬输尿管节段的高强度、高频、短持续时间刺激，增强了以每分钟3次的基础频率对长时间刺激产生收缩的节段的收缩力。当将这些相同的高强度、高频、短持续时间刺激施加于用酚妥拉明预处理的输尿管节段时，基础驱动制剂所产生的张力降低。这些数据表明犬和兔输尿管中存在α - 刺激型和β - 抑制型肾上腺素能受体，并为输尿管壁内可影响收缩力的肾上腺素能组织提供了证据。
