Zhen F, Tian J, Li L S
Dept. of Nephrology, Jinling Hospital, Nanjing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 May;12(5):288-91, 262.
Nephrotoxic ARF model of rat was induced by IP injection of either Gentamycin or Kanamycin and treated with CS. The results of study showed that the simultaneous administration of CS with Gentamycin could protect the proximal tubular cells from Gentamycin toxicity and the use of CS after the establishment of Kanamycin nephrotoxic ARF could prompt an earlier recovery from ARF as compared with the control group. The possible mechanisms of CS on ARF include: (1) protecting tubular cell sodium pump activity; (2) attenuating tubular cell lysosome overfunction stimulated by phagocytosis of aminoglycoside; (3) decreasing tubular cell lipoperoxidation in response to toxic injury.
通过腹腔注射庆大霉素或卡那霉素诱导大鼠肾毒性急性肾衰竭（ARF）模型，并给予CS进行治疗。研究结果表明，CS与庆大霉素同时给药可保护近端肾小管细胞免受庆大霉素毒性影响，并且在卡那霉素肾毒性ARF模型建立后使用CS，与对照组相比，可促使ARF更早恢复。CS对ARF的可能作用机制包括：（1）保护肾小管细胞钠泵活性；（2）减弱由氨基糖苷吞噬刺激引起的肾小管细胞溶酶体功能亢进；（3）减少肾小管细胞因毒性损伤而产生的脂质过氧化。
