Tang S
Insulin Research Laboratory, West China University of Medical Sciences, Chengdu.
Zhonghua Yi Xue Za Zhi. 1992 Apr;72(4):222-4, 255.
To investigate the role of glucagon in the pathogenesis of diabetes, we observed change of plasma glucagon concentrations during glucose loading in normal subjects and patients with impaired glucose tolerance (IGT) and non-insulin dependent diabetes mellitus (NIDDM) using specific radioimmunoassay. The results showed that the fasting plasma glucagon levels in patients with IGT and NIDDM were similar to those of the normal subjects. The nadir of plasma glucagon level in the normal control occurred at 1-h after glucose loading and the changes of glucagon, glucose and insulin levels synchronized; but peaks of plasma glucose and insulin levels in the IGT and NIDDM patients were delayed at 2-h after glucose loading with the lowest glucagon level at 3-h. It was suggested that there were relative hyperglucagonemia and decrease of sensitivity of islet A cell to glucose in IGT and NIDDM patients. The present study also showed that hyperglucagonemia is related to the reduction of insulin secretion and might play an important role in the development of postprandial hyperglycemia in NIDDM.
为了研究胰高血糖素在糖尿病发病机制中的作用，我们采用特异性放射免疫分析法，观察了正常受试者、糖耐量受损（IGT）患者和非胰岛素依赖型糖尿病（NIDDM）患者在葡萄糖负荷试验期间血浆胰高血糖素浓度的变化。结果显示，IGT患者和NIDDM患者的空腹血浆胰高血糖素水平与正常受试者相似。正常对照组血浆胰高血糖素水平的最低点出现在葡萄糖负荷后1小时，且胰高血糖素、葡萄糖和胰岛素水平的变化同步；但IGT患者和NIDDM患者血浆葡萄糖和胰岛素水平的峰值在葡萄糖负荷后2小时延迟出现，胰高血糖素水平最低值出现在3小时。提示IGT患者和NIDDM患者存在相对高胰高血糖素血症以及胰岛A细胞对葡萄糖的敏感性降低。本研究还表明，高胰高血糖素血症与胰岛素分泌减少有关，可能在NIDDM患者餐后高血糖的发生中起重要作用。
