Sun Q
Zhonghua Yi Xue Za Zhi. 1989 Apr;69(4):198-9, 16.
The plasma glucose and insulin response to oral glucose or carbohydrate meal tolerance tests were determined in 78 normal controls, 71 persons with IGT and 110 patients with NIDDM. The results showed that: (1) The fasting serum insulin levels and insulin/glucose ratio were all higher in persons with IGT than those in the normal controls, and they were normal in diabetics with fasting plasma glucose less than 7.8 mmol/L. In diabetics with fasting plasma glucose at 7.8-20.3 mmol/L, fasting insulin levels were within normal limit, but the values of insulin/glucose ratio were significantly decreased. (2) After glucose challenge, the values of serum insulin/glucose ratio were all increased in IGT, but were progressively decreased in diabetics as fasting plasma glucose gradually became higher. (3) Fasting serum insulin levels were increased in normal weight and over-weight individuals with IGT. But in those with diabetes, fasting insulin was increased in comparison with normal controls. When fasting plasma glucose was greater than 11.1 mmol/L, insulin/glucose ratio was decreased significantly. Our data suggests that the increased insulin secretion in persons with IGT was due to peripheral resistance and relative insulin insufficiency, and that hyperglycemia could compensate for B cell impairment.
对78名正常对照者、71名糖耐量受损（IGT）者和110名非胰岛素依赖型糖尿病（NIDDM）患者进行了口服葡萄糖或碳水化合物餐耐量试验，测定其血浆葡萄糖和胰岛素反应。结果显示：（1）IGT者的空腹血清胰岛素水平和胰岛素/葡萄糖比值均高于正常对照者，空腹血糖低于7.8 mmol/L的糖尿病患者这些指标正常。空腹血糖在7.8 - 20.3 mmol/L的糖尿病患者，空腹胰岛素水平在正常范围内，但胰岛素/葡萄糖比值显著降低。（2）葡萄糖激发后，IGT者血清胰岛素/葡萄糖比值均升高，但糖尿病患者随着空腹血糖逐渐升高该比值逐渐降低。（3）正常体重和超重的IGT者空腹血清胰岛素水平升高。但糖尿病患者与正常对照者相比空腹胰岛素升高。当空腹血糖大于11.1 mmol/L时，胰岛素/葡萄糖比值显著降低。我们的数据表明，IGT者胰岛素分泌增加是由于外周抵抗和相对胰岛素不足，且高血糖可代偿β细胞功能损害。
