吸入发射α粒子的锕系元素对小鼠肺泡巨噬细胞的影响。
Effects of inhaled alpha-emitting actinides on mouse alveolar macrophages.
作者信息
Morgan A, Talbot R J
机构信息
Biomedical Research Department, AEA Environment and Energy, Harwell Laboratory, Oxfordshire, UK.
出版信息
Environ Health Perspect. 1992 Jul;97:177-84. doi: 10.1289/ehp.9297177.
Abstract
The effects of inhaled alpha-emitting actinides on the alveolar macrophage (AM) population of the rodent lung are reviewed and, in particular, of the effects of 239PuO2 on murine AM. The effects discussed include changes the AM pool size, macrophage diameter, mobility, phagocytic competence, and enzyme content. Finally, similarities in the dose-response relationships for the induction of nuclear aberrations by alpha emitters and in the induction of lung tumors by the same materials are noted.
摘要
本文综述了吸入发射α粒子的锕系元素对啮齿动物肺部肺泡巨噬细胞（AM）群体的影响，特别是239PuO2对小鼠AM的影响。所讨论的影响包括AM池大小、巨噬细胞直径、迁移率、吞噬能力和酶含量的变化。最后，指出了α发射体诱导核畸变与相同物质诱导肺癌的剂量反应关系的相似性。
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本文引用的文献
1
THE CYTOLOGIC DEMONSTRATION OF BETA-GLUCURONIDASE EMPLOYING NAPHTHOL AS-BI GLUCURONIDE AND HEXAZONIUM PARAROSANILIN; A PRELIMINARY REPORT.使用萘酚 AS - BI 葡糖苷酸和副品红六偶氮化物进行β - 葡糖醛酸酶的细胞化学显示：初步报告。
J Histochem Cytochem. 1964 Apr;12:293-7. doi: 10.1177/12.4.293.
2
Dose-dependent effects in the subacute response of the rat lung to quartz. I. The cellular response and the activity of lactate dehydrogenase in the airways.大鼠肺对石英亚急性反应中的剂量依赖性效应。I. 气道中的细胞反应及乳酸脱氢酶活性
Exp Lung Res. 1983 Dec;5(4):229-43. doi: 10.3109/01902148309061517.
3
Phagocytosis of inhaled plutonium oxide-239pu particles by pulmonary macrophages.
Science. 1968 Nov 22;162(3856):918-20. doi: 10.1126/science.162.3856.918.
4
[Measurement of migration, in vitro, of alveolar histiocytes: comparative action of antiserums and plutonium oxide poisoning].
C R Acad Hebd Seances Acad Sci D. 1972 Jan 3;274(1):77-80.
5
The development and interlobar distribution of plutonium-induced pulmonary fibrosis in mice.
Radiat Res. 1985 Jul;103(1):135-48.
6
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7
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8
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