Hovda D A, Chugani H T, Villablanca J R, Badie B, Sutton R L
Department of Surgery/Neurosurgery, UCLA School of Medicine 90024-6901.
J Cereb Blood Flow Metab. 1992 Nov;12(6):1039-48. doi: 10.1038/jcbfm.1992.141.
The maturation of brain oxidative capacity was studied in kittens, using cytochrome oxidase histochemistry, at different ages throughout development. Optical densitometry values of reacted tissue were obtained for 50 different structures of the brain. In general, most structures reached adult levels of oxidative capacity by 30 days of age with some motor areas (e.g., cerebellum, red nucleus) exhibiting adult values as early as 7 days of age. Thereafter, some structures (e.g., basal ganglia, thalamus) exhibited levels of cytochrome oxidase activity that exceeded adult values for varying periods of time. These findings indicate regional heterogeneity in the maturation of cerebral oxidative capacity. Furthermore, these maturational patterns appear to correlate well with previous observations from anatomical, physiological and neurobehavioral studies.
利用细胞色素氧化酶组织化学方法，在小猫发育的不同年龄阶段研究了脑氧化能力的成熟情况。对脑的50个不同结构获取了反应组织的光密度测量值。一般来说，大多数结构在30日龄时达到成年期的氧化能力水平，一些运动区域（如小脑、红核）早在7日龄时就呈现出成年期的值。此后，一些结构（如基底神经节、丘脑）在不同时间段内呈现出超过成年期值的细胞色素氧化酶活性水平。这些发现表明脑氧化能力成熟过程中存在区域异质性。此外，这些成熟模式似乎与先前解剖学、生理学和神经行为学研究的观察结果密切相关。
