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具有吗啡样作用的合成物质；化学结构与镇痛作用之间的关系。

Synthetic substances with morphine-like effect; relationship between chemical structure and analgesic action.

作者信息

BRAENDEN O J, EDDY N B, HALBACH H

出版信息

Bull World Health Organ. 1955;13(6):937-98.

PMID:13284565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2538094/
Abstract

For morphine-, morphinan-, pethidine-, methadone-, and dithienyl-butenylamine groups of analgesic compounds a systematic survey is given of how analgesic activity is quantitatively affected by alteration of the chemical constitution. Features common to the structural formulae of substances with morphine-like analgesic effect are pointed out.

摘要

对于吗啡、吗啡喃、哌替啶、美沙酮和二噻吩丁烯胺类镇痛化合物，系统综述了化学结构的改变如何定量影响镇痛活性。指出了具有吗啡样镇痛作用的物质结构式的共同特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a68/2538094/c2e0b01f17e1/bullwho00545-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a68/2538094/1d40cb48a261/bullwho00545-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a68/2538094/c2e0b01f17e1/bullwho00545-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a68/2538094/1d40cb48a261/bullwho00545-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a68/2538094/c2e0b01f17e1/bullwho00545-0061-a.jpg

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1
Synthetic substances with morphine-like effect; relationship between chemical structure and analgesic action.具有吗啡样作用的合成物质；化学结构与镇痛作用之间的关系。
Bull World Health Organ. 1955;13(6):937-98.
2
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[Structure-activity relationships of analgesics].
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4
[The analgesic action of d-phenylalanine in combination with morphine or methadone].
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引用本文的文献

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Synthesis and Modification of Morphine and Codeine, Leading to Diverse Libraries with Improved Pain Relief Properties.吗啡和可待因的合成与修饰，生成具有改善止痛特性的多样文库。
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A new series of analgesics.一系列新型镇痛药。
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