Shaskan E G, Brew B J, Rosenblum M, Thompson R M, Price R W
Department of Neurology, University of Minnesota, Minneapolis 55455-0323.
J Neurochem. 1992 Oct;59(4):1541-6. doi: 10.1111/j.1471-4159.1992.tb08471.x.
Postmortem levels of native neopterin (D-erythro-neopterin) were measured in cerebral cortical samples from 44 human immunodeficiency virus type 1-infected and eight uninfected, nonneurological control patients. Cerebral cortical gray and white matter neopterin levels for the controls ranged from 0.5 to 7.2 pmol/mg of protein in contrast to neopterin levels in brains of the virus-infected patients, which frequently were more than threefold and occasionally more than 30-fold higher than mean control levels. Cortical neopterin levels did not correlate with severity of the acquired immunodeficiency syndrome dementia complex, but subcortical levels correlated with the presence of active human immunodeficiency virus type 1 infection, as reflected by pathological evidence of multinucleated giant cell encephalitis. Evidence of opportunistic cytomegalovirus infections in approximately 25% of the human immunodeficiency virus type 1-infected patients was associated with enhanced levels of neopterin in frontal cortex.
在44例感染1型人类免疫缺陷病毒（HIV-1）的患者以及8例未感染且无神经疾病的对照患者的大脑皮质样本中，检测了天然新蝶呤（D-赤藓糖型新蝶呤）的尸检水平。对照组大脑皮质灰质和白质中的新蝶呤水平为每毫克蛋白质0.5至7.2皮摩尔，相比之下，病毒感染患者大脑中的新蝶呤水平常常比对照组平均水平高出三倍以上，偶尔高出30倍以上。皮质新蝶呤水平与获得性免疫缺陷综合征痴呆综合征的严重程度无关，但皮质下水平与1型人类免疫缺陷病毒活跃感染的存在相关，多核巨细胞性脑炎的病理证据反映了这一点。约25%的1型人类免疫缺陷病毒感染患者存在机会性巨细胞病毒感染的证据，这与额叶皮质中更高水平的新蝶呤有关。
