Sawada M, Hirata Y, Arai H, Iizuka R, Nagatsu T
J Neurochem. 1987 Mar;48(3):760-4. doi: 10.1111/j.1471-4159.1987.tb05582.x.
The activities of tyrosine hydroxylase and tryptophan hydroxylase, and the concentrations of the biopterin cofactor and the precursor neopterin were measured in 14 regions of postmortem brains from four histologically verified patients of senile dementia of the Alzheimer type (SDAT) and eight histologically normal controls. Neopterin concentrations were measured in the human brain for the first time. The activities of tyrosine hydroxylase and tryptophan hydroxylase in the brains of patients with SDAT were significantly reduced in the substantia nigra and in the lateral segment of the globus pallidus, locus ceruleus, and substantia nigra, respectively. The concentrations of total biopterin in the brains of patients with SDAT were significantly reduced in the putamen and substantia nigra, but the total neopterin concentrations did not change significantly. These results suggest that the reduction in biogenic amines in SDAT might be related to reductions in biosynthetic enzymes associated with biogenic amines, due to destruction of monoaminergic neurons.
对4例经组织学证实的阿尔茨海默型老年性痴呆（SDAT）患者和8例组织学正常对照者的尸检大脑14个区域，测定了酪氨酸羟化酶和色氨酸羟化酶的活性，以及生物蝶呤辅因子和前体新蝶呤的浓度。首次在人脑中测定了新蝶呤浓度。SDAT患者大脑中，酪氨酸羟化酶活性在黑质显著降低，色氨酸羟化酶活性分别在苍白球外侧段、蓝斑和黑质显著降低。SDAT患者大脑中，壳核和黑质的总生物蝶呤浓度显著降低，但总新蝶呤浓度无显著变化。这些结果表明，SDAT中生物胺的减少可能与生物胺相关生物合成酶的减少有关，这是由于单胺能神经元的破坏所致。
