氨己烯酸对纹状体多巴胺受体的影响：人类中γ-氨基丁酸（GABA）与多巴胺系统相互作用的证据。
Effect of vigabatrin on striatal dopamine receptors: evidence in humans for interactions of GABA and dopamine systems.
作者信息
Ring H A, Trimble M R, Costa D C, George M S, Verhoeff P, Ell P J
机构信息
Raymond Way Neuropsychiatry Research Group, Institute of Neurology, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1992 Sep;55(9):758-61. doi: 10.1136/jnnp.55.9.758.
Abstract
Vigabatrin is a specific gamma-aminobutyric acid transaminase inhibitor. The clinical use of this drug in the treatment of epilepsy has been sporadically linked to the development of psychosis. Using 123I-IBZM, a specific dopamine D2 receptor ligand and single photon emission tomography (SPET), one month of treatment with vigabatrin was associated with a decrease in specific binding of 123I-IBZM to D2 receptors in the left hemisphere basal ganglia. This change may provide one explanation for the development of psychosis in vulnerable patients.
摘要
氨己烯酸是一种特异性γ-氨基丁酸转氨酶抑制剂。该药物在癫痫治疗中的临床应用偶尔与精神病的发生有关。使用123I-碘苄胍（一种特异性多巴胺D2受体配体）和单光子发射断层扫描（SPET），氨己烯酸治疗一个月与左半球基底神经节中123I-碘苄胍与D2受体的特异性结合减少有关。这种变化可能为易感患者发生精神病提供一种解释。
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