某些四环素类抗生素氧化过程中产生的极微弱化学发光。1. 自动氧化。
The extra-weak chemiluminescence generated during oxidation of some tetracycline antibiotics. 1. Autoxidation.
作者信息
Kruk I, Lichszteld K, Michalska T, Nizinkiewicz K, Wrońska J
机构信息
Institute of Physics, Technical University of Szczecin, Poland.
出版信息
J Photochem Photobiol B. 1992 Jul 30;14(4):329-43. doi: 10.1016/1011-1344(92)85112-8.
Chemiluminescence (CL) appearing during autoxidation of tetracycline (TC) antibiotics has been studied. The CL spectrum consists of four emission bands with maxima at 520, 585, 640 and 700 nm. The bands at 585, 640 and 700 nm are similar to those observed for singlet molecular oxygen (1O2). The effect of 1O2 quenchers and free radical reaction inhibitors on the light emission is also reported. The data support the concept that, during the autoxidation of TCs, cytotoxic oxygen species such as HO., O2.-, H2O2 and 1O2 are formed.
对四环素（TC）类抗生素自氧化过程中出现的化学发光（CL）进行了研究。化学发光光谱由四个发射带组成，其最大值分别位于520、585、640和700nm处。585、640和700nm处的发射带与单重态分子氧（1O2）所观察到的发射带相似。还报道了1O2猝灭剂和自由基反应抑制剂对发光的影响。数据支持这样一种概念，即在四环素类抗生素的自氧化过程中，会形成细胞毒性氧物种，如羟基自由基（HO·）、超氧阴离子（O2-·）、过氧化氢（H2O2）和单重态分子氧（1O2）。
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