Ottaviani E, Trevisan P, Pederzoli A
Department of Animal Biology, University of Modena, Italy.
Peptides. 1992 Mar-Apr;13(2):227-31. doi: 10.1016/0196-9781(92)90101-8.
Using immunocytochemical procedures and RIA tests, the presence of immunoreactive ACTH and beta-endorphin molecules in the basophils and neutrophils of urodelan amphibians (Salamandra s. salamandra, Triturus c. carnifex, Speleomantes imperialis) has been established. Moreover, it was observed that not only neutrophils but also basophils have phagocytic activity. The findings reported suggest that: 1) a relationship exists between the immune and neuroendocrine systems, and 2) the opioid-like molecules play a physiological role in the process of phagocytosis. Indeed, ACTH increases the phagocytic activity.
运用免疫细胞化学方法和放射免疫分析测试，已确定在有尾两栖动物（真螈、意大利真螈、帝王洞螈）的嗜碱性粒细胞和中性粒细胞中存在免疫反应性促肾上腺皮质激素（ACTH）和β-内啡肽分子。此外，还观察到不仅中性粒细胞而且嗜碱性粒细胞都具有吞噬活性。所报告的研究结果表明：1）免疫和神经内分泌系统之间存在关联，2）阿片样分子在吞噬过程中发挥生理作用。事实上，促肾上腺皮质激素会增强吞噬活性。
