通过体内31P磁共振波谱检查照射对脑和小细胞肺癌的不同早期效应。

Different early effect of irradiation in brain and small cell lung cancer examined by in vivo 31P-magnetic resonance spectroscopy.

作者信息

Kristjansen P E, Pedersen A G, Quistorff B, Spang-Thomsen M

机构信息

Department of Oncology, Finsen Institute, Blegdamsvej, Copenhagen, Denmark.

出版信息

Radiother Oncol. 1992 Jul;24(3):186-90. doi: 10.1016/0167-8140(92)90378-8.

DOI:10.1016/0167-8140(92)90378-8

PMID:1329155

Abstract

Early effects of irradiation were evaluated by non-invasive in vivo 31P-magnetic resonance spectroscopy (31P-MRS) of two small cell lung cancer (SCLC) tumor lines CPH SCCL 54A and 54B, in nude mice. The tumors were originally derived from the same patient and have similar morphology and growth characteristics, but a different radiosensitivity. The 54A tumors are twice as radiosensitive as the 54B's. In the present study the tumors were treated with 2.5, 10, and 40 Gy. For comparison, nude mice were given cranial irradiation at the same three doses, and the effect was evaluated by in vivo 31P-MRS. No effect was observed in brain at any dose level. In contrast, 40 Gy induced a statistically significant reduction in ATP/Pi ratio during the 12-h post-irradiation period. This effect was more pronounced in 54A than in 54B. Some reduction was observed following 10 Gy, whereas 2.5 Gy induced no changes in ATP/Pi. The differential effect on tumors and brain might be relevant for monitoring irradiation effects by in vivo 31P-MRS in patients with brain metastases.

摘要

通过对裸鼠体内两个小细胞肺癌（SCLC）肿瘤系CPH SCCL 54A和54B进行非侵入性体内31P磁共振波谱（31P-MRS）分析，评估辐射的早期效应。这些肿瘤最初来源于同一患者，具有相似的形态和生长特征，但放射敏感性不同。54A肿瘤的放射敏感性是54B肿瘤的两倍。在本研究中，肿瘤分别接受2.5、10和40 Gy的照射。作为对照，给裸鼠头部施以相同的三种剂量照射，并通过体内31P-MRS评估其效果。在任何剂量水平下，脑部均未观察到效应。相反，40 Gy照射后12小时内，ATP/Pi比值出现统计学上的显著降低。这种效应在54A肿瘤中比在54B肿瘤中更明显。10 Gy照射后观察到一些降低，而2.5 Gy照射未引起ATP/Pi的变化。对肿瘤和脑部的不同效应可能与通过体内31P-MRS监测脑转移患者的照射效果有关。