Sinha D P, Mitchell M J
Safety Evaluation Center, Schering-Plough Research, Lafayette, New Jersey 07848.
Toxicol Pathol. 1992;20(1):131-3. doi: 10.1177/019262339202000118.
In a 3-month oral toxicity study of a pharmaceutical agent, intranuclear inclusions were seen in the secretory cells of the pars anterior of the pituitary gland of 22 of 40 cynomolgus monkeys, with similar incidences in control and dosed groups. All monkeys were clinically healthy. Electron microscopic examination revealed that the intranuclear inclusions were cytoplasmic invaginations.
在一项药物的3个月口服毒性研究中，40只食蟹猴中有22只的垂体前叶分泌细胞出现核内包涵体，对照组和给药组的发生率相似。所有猴子临床均健康。电子显微镜检查显示，核内包涵体为细胞质内陷。
