Süsal C, Groth J, Oberg H H, Terness P, May G, Opelz G
Department of Transplantation Immunology, University of Heidelberg, Germany.
Transplantation. 1992 Oct;54(4):632-5. doi: 10.1097/00007890-199210000-00012.
Pretransplant sera of 474 kidney graft recipients were tested for IgG-anti-F(ab')2 gamma activity. The patients had significantly higher IgG-anti-F(ab')2 gamma activity than healthy controls (P = 0.0004). Serum lymphocytotoxic antibodies were correlated with IgG-anti-F(ab')2 gamma (P = 0.004), whereas CMV infection and blood transfusions were not. We found a significant association between pretransplant IgG-anti-F(ab')2 gamma activity and early and 1-year kidney graft outcome. This association was pronounced in recipients with no lymphocytotoxic antibodies. Recipients with immediately functioning grafts and a creatinine < 130 mumol/L at 1 year had strikingly higher pretransplant IgG-anti-F(ab')2 gamma activity than patients with graft failure (P < 0.0001).
对474名肾移植受者的移植前血清进行了IgG抗F(ab')2γ活性检测。患者的IgG抗F(ab')2γ活性显著高于健康对照者（P = 0.0004）。血清淋巴细胞毒性抗体与IgG抗F(ab')2γ相关（P = 0.004），而巨细胞病毒感染和输血则无相关性。我们发现移植前IgG抗F(ab')2γ活性与早期及1年肾移植结局之间存在显著关联。这种关联在无淋巴细胞毒性抗体的受者中尤为明显。移植后立即功能良好且1年时肌酐<130μmol/L的受者，其移植前IgG抗F(ab')2γ活性显著高于移植失败的患者（P < 0.0001）。
