McArdle F, Bennett M, Gaskell R M, Tennant B, Kelly D F, Gaskell C J
Department of Veterinary Pathology, University of Liverpool Field Station, Neston, Wirral, UK.
Am J Vet Res. 1992 Sep;53(9):1500-6.
Preexisting antibody to feline infectious peritonitis virus (FIPV) causes acceleration and enhancement of disease on subsequent infection of cats with FIPV. Other workers have shown that canine coronavirus (CCV) can infect cats subclinically, but have found no evidence of enhancement of, or protection against, subsequent FIPV infection. With various isolates of CCV, we determined that 1 strain of CCV can induce transient mild diarrhea in cats and, furthermore, that previous infection with CCV causes acceleration and enhancement of subsequent infection with FIPV. In addition, sequential inoculation of cats with another strain of CCV caused lesions indistinguishable from those of FIP, without exposure at any time to FIPV.
猫传染性腹膜炎病毒（FIPV）的预先存在的抗体，会在猫随后感染FIPV时导致疾病加速和病情加重。其他研究人员表明，犬冠状病毒（CCV）可在猫身上引起亚临床感染，但未发现有证据表明其对随后的FIPV感染有增强作用或保护作用。对于各种CCV分离株，我们确定1株CCV可在猫身上诱发短暂的轻度腹泻，此外，先前感染CCV会导致随后感染FIPV时病情加速和加重。此外，用另一株CCV对猫进行连续接种会导致与猫传染性腹膜炎（FIP）难以区分的病变，且在任何时候都未接触FIPV。
