Yates A J
Division of Neuropathology, Ohio State University, Columbus 43210.
Mol Chem Neuropathol. 1992 Oct;17(2):103-20. doi: 10.1007/BF03159986.
The purpose of this review is to clarify for the nonneuropathologist some of the confusing issues concerning the classification of brain tumors. Following a short discussion of the commonly used methods to diagnose brain tumors clinically (frozen section, light and electron microscopy, immunohistochemistry), the general principles of classifying neural tumors are presented. Grading of tumors on the basis of histological anaplasia, and the concept that tumor cells can be related to specific cytological stages of normal cellular development (cytogenetic classification) are presented. The World Health Organization system of classifying neural tumors is an attempt to develop a standardized classification scheme with as few interpretative controversies as possible, but it has required revision as new information has been gained. The major clinical and biological features of the commonest tumor groups are then discussed. It is unlikely that improvements in the classification of brain tumors will be based solely on histological information. Definitions of tumor entities that will provide more accurate prognoses and bases for effective therapy will require considerably more information at the molecular level than is currently available.
本综述的目的是为非神经病理学家澄清一些关于脑肿瘤分类的令人困惑的问题。在简短讨论临床诊断脑肿瘤常用方法（冰冻切片、光镜和电镜、免疫组化）之后，介绍了神经肿瘤分类的一般原则。阐述了基于组织学间变程度的肿瘤分级，以及肿瘤细胞可与正常细胞发育的特定细胞学阶段相关的概念（细胞遗传学分类）。世界卫生组织的神经肿瘤分类系统旨在制定一个标准化分类方案，尽量减少解释上的争议，但随着新信息的获取，该系统需要修订。接着讨论了最常见肿瘤组的主要临床和生物学特征。脑肿瘤分类的改进不太可能仅基于组织学信息。要定义能提供更准确预后和有效治疗依据的肿瘤实体，在分子水平上需要比目前更多的信息。
