Sharma R, Venkatasubramanian P N, Bárány M, Davis J M
Department of Psychiatry, College of Medicine, University of Illinois, Chicago.
Schizophr Res. 1992 Oct;8(1):43-9. doi: 10.1016/0920-9964(92)90059-e.
Water-suppressed 1H magnetic resonance spectra were recorded from two brain regions of psychiatric patients and normal volunteers. The two regions studied were (a) the basal ganglia structures surrounding the anterior horn of the lateral ventricle and (b) the occipital cortex. N-Acetylaspartate (NAA), phosphocreatine-creatine (PCr-Cr), choline and inositol resonances were seen in both regions. Ratios of metabolite peak integrals to PCr-Cr peak integral were calculated for each spectrum. To control for partial volume effects, comparisons between patients and controls were made only from identical regions i.e. basal ganglia vs basal ganglia, and likewise for occipital cortex. Metabolite ratios from the occipital region of patients were similar to those from the occipital region of normal subjects. Bipolar patients being treated with lithium had elevated NAA/PCr-Cr in the basal ganglia region when compared to normals. These patients also demonstrated elevated choline/PCr-Cr and inositol/PCr-Cr ratios in the basal ganglia region.
对精神病患者和正常志愿者的两个脑区进行了水抑制1H磁共振波谱记录。所研究的两个区域为：(a)侧脑室前角周围的基底节结构；(b)枕叶皮质。在这两个区域均可见到N-乙酰天门冬氨酸（NAA）、磷酸肌酸-肌酸（PCr-Cr）、胆碱和肌醇的共振峰。计算每个波谱中代谢物峰积分与PCr-Cr峰积分的比值。为控制部分容积效应，仅在相同区域（即基底节与基底节、枕叶皮质与枕叶皮质）对患者和对照进行比较。患者枕叶区域的代谢物比值与正常受试者枕叶区域的相似。与正常人相比，接受锂治疗的双相情感障碍患者基底节区域的NAA/PCr-Cr升高。这些患者基底节区域的胆碱/PCr-Cr和肌醇/PCr-Cr比值也升高。
