Stone A A, Bovbjerg D H, Neale J M, Napoli A, Valdimarsdottir H, Cox D, Hayden F G, Gwaltney J M
Department of Psychiatry, State University of New York, Stony Brook.
Behav Med. 1992 Fall;18(3):115-20. doi: 10.1080/08964289.1992.9936961.
Previous studies of rhinovirus infection indicate that about one third of the persons with confirmed viral infection do not show evidence of cold symptoms. Factors that determine which infected individuals will develop colds are not known. Using a rhinovirus inoculation protocol, the authors explored the possible role of recent life events, current mood, and perceived stress in the development of symptoms in individuals known to be infected. As part of a larger study, 17 subjects were exposed to a rhinovirus and were individually isolated for 5 consecutive days; cold symptoms, mucus weights, and tissue use were monitored on a daily basis during this period. Although all 17 subjects had confirmed rhinovirus infection, only 12 subjects developed clinical colds, as indicated by self-reported symptoms and by objective symptom indices. The average number of reported major life events for the previous year was significantly higher for those who developed colds than for those who did not (p < .05). Measures of affect and perceived stress before the inoculation were not different for those who did and did not develop colds. Complementing recent research demonstrating psychosocial influences on experimental infection rates, these results provide evidence that the development of cold symptomatology in experimentally infected individuals is related to prior life events.
先前关于鼻病毒感染的研究表明，约三分之一确诊病毒感染的人没有出现感冒症状的迹象。决定哪些受感染个体将会患上感冒的因素尚不清楚。作者采用鼻病毒接种方案，探究了近期生活事件、当前情绪和感知到的压力在已知受感染个体出现症状过程中可能起到的作用。作为一项更大规模研究的一部分，17名受试者接触了鼻病毒，并连续5天被单独隔离；在此期间，每天监测感冒症状、黏液重量和纸巾使用情况。尽管所有17名受试者都确诊感染了鼻病毒，但根据自我报告症状和客观症状指标显示，只有12名受试者出现了临床感冒症状。与未患感冒的人相比，患感冒的人在前一年报告的重大生活事件平均数量显著更高（p < 0.05）。接种前的情绪和感知压力测量结果在患感冒和未患感冒的人之间并无差异。这些结果补充了近期关于心理社会因素对实验感染率有影响的研究，证明了在实验感染个体中感冒症状的出现与先前生活事件有关。
