Chiba S, Tsukada M
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Eur J Pharmacol. 1992 Oct 20;221(2-3):393-5. doi: 10.1016/0014-2999(92)90730-r.
Using a perfusion technique with isolated vessels, we investigated the effect of OPC-21268 (a selective V1 receptor antagonist) and OPC-31260 (a V2 receptor antagonist) on arginine vasopressin (AVP)- or norepinephrine (NE)-induced vasoconstrictions of isolated simian femoral arteries. The dose-response curve for AVP was shifted to the right in parallel by OPC-31260 but not by OPC-21268. Neither antagonist significantly modified the NE-induced vasoconstriction. On the basis of these results, there are functionally constrictory vasopressin V2 receptors but no V1 receptors in isolated simian femoral arteries.
利用离体血管灌注技术，我们研究了OPC - 21268（一种选择性V1受体拮抗剂）和OPC - 31260（一种V2受体拮抗剂）对精氨酸加压素（AVP）或去甲肾上腺素（NE）诱导的离体猿猴股动脉血管收缩的影响。OPC - 31260使AVP的剂量 - 反应曲线平行右移，而OPC - 21268则无此作用。两种拮抗剂均未显著改变NE诱导的血管收缩。基于这些结果，在离体猿猴股动脉中存在功能性的血管收缩性血管加压素V2受体，但不存在V1受体。
