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干扰二酰基甘油代谢对单个肝细胞中诱导的胞质游离钙离子振荡的影响。

Effect of perturbing diacylglycerol metabolism on cytosolic free Ca2+ oscillations induced in single hepatocytes.

作者信息

Sanchez-Bueno A, Cobbold P H

机构信息

Department of Human Anatomy and Cell Biology, University of Liverpool, UK.

出版信息

FEBS Lett. 1992 Nov 2;312(1):57-60. doi: 10.1016/0014-5793(92)81409-f.

DOI:10.1016/0014-5793(92)81409-f
PMID:1330680
Abstract

Single rat hepatocytes microinjected with aequorin show free Ca oscillations when stimulated with Ca(2+)-mobilizing hormones. We show here that an inhibitor of diacylglycerol kinase (R 59 022) and an analogue of native diacylglycerol (diC8) inhibit free Ca oscillations induced by phenylephrine and vasopressin. These results agree with a negative feedback effect of protein kinase C on free Ca oscillations.

摘要

用水母发光蛋白显微注射的单个大鼠肝细胞在用钙动员激素刺激时会出现游离钙振荡。我们在此表明，二酰基甘油激酶抑制剂（R 59 022）和天然二酰基甘油类似物（二C8）可抑制去甲肾上腺素和血管加压素诱导的游离钙振荡。这些结果与蛋白激酶C对游离钙振荡的负反馈作用一致。

相似文献

1
Effect of perturbing diacylglycerol metabolism on cytosolic free Ca2+ oscillations induced in single hepatocytes.干扰二酰基甘油代谢对单个肝细胞中诱导的胞质游离钙离子振荡的影响。
FEBS Lett. 1992 Nov 2;312(1):57-60. doi: 10.1016/0014-5793(92)81409-f.
2
Modulation of cytosolic-[Ca2+] oscillations in hepatocytes results from cross-talk among second messengers. The synergism between the alpha 1-adrenergic response, glucagon and cyclic AMP, and their antagonism by insulin and diacylglycerol manifest themselves in the control of the cytosolic-[Ca2+] oscillations.肝细胞中胞质[Ca2+]振荡的调节源于第二信使之间的相互作用。α1-肾上腺素能反应、胰高血糖素和环磷酸腺苷之间的协同作用，以及它们与胰岛素和二酰基甘油之间的拮抗作用，在胞质[Ca2+]振荡的控制中得以体现。
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Diacylglycerol kinase inhibitors R59022 and dioctanoylethylene glycol potentiate the respiratory burst of neutrophils by raising cytosolic Ca2+.二酰基甘油激酶抑制剂R59022和二辛酰基乙二醇通过提高胞质Ca2+增强中性粒细胞的呼吸爆发。
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Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes.在单个装载fura-2的肝细胞中由去氧肾上腺素和加压素诱导的胞质钙振荡的特征分析
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Fluoroaluminate mimics agonist application in single rat hepatocytes.氟铝酸盐在单个大鼠肝细胞中模拟激动剂的作用。
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Different modulatory effects of elevated cyclic AMP on cytosolic Ca2+ spikes induced by phenylephrine or vasopressin in single rat hepatocytes.环磷酸腺苷升高对苯肾上腺素或血管加压素诱导的单个大鼠肝细胞胞质钙离子峰的不同调节作用。
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Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes.激动剂诱导的单个大鼠肝细胞胞质游离钙浓度振荡
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Thimerosal enhances agonist-specific differences between [Ca2+]i oscillations induced by phenylephrine and ATP in single rat hepatocytes.硫柳汞增强了苯肾上腺素和三磷酸腺苷在单个大鼠肝细胞中诱导的[Ca2+]i振荡之间的激动剂特异性差异。
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R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet.R 59 022，一种二酰基甘油激酶抑制剂。它对完整血小板中由二酰基甘油和凝血酶诱导的C激酶激活的影响。
J Biol Chem. 1985 Dec 15;260(29):15762-70.

引用本文的文献

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Agonist-specific behaviour of the intracellular Ca2+ response in rat hepatocytes.大鼠肝细胞内钙离子反应的激动剂特异性行为
Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):573-9. doi: 10.1042/bj3280573.
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Suppression of agonist induced Ca2+ oscillations in cultured hepatocytes by nafenopin: possible involvement of protein kinase C.萘酚平对培养肝细胞中激动剂诱导的Ca2+振荡的抑制作用：蛋白激酶C的可能参与
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