干扰二酰基甘油代谢对单个肝细胞中诱导的胞质游离钙离子振荡的影响。
Effect of perturbing diacylglycerol metabolism on cytosolic free Ca2+ oscillations induced in single hepatocytes.
作者信息
Sanchez-Bueno A, Cobbold P H
机构信息
Department of Human Anatomy and Cell Biology, University of Liverpool, UK.
出版信息
FEBS Lett. 1992 Nov 2;312(1):57-60. doi: 10.1016/0014-5793(92)81409-f.
PMID:1330680
Abstract
Single rat hepatocytes microinjected with aequorin show free Ca oscillations when stimulated with Ca(2+)-mobilizing hormones. We show here that an inhibitor of diacylglycerol kinase (R 59 022) and an analogue of native diacylglycerol (diC8) inhibit free Ca oscillations induced by phenylephrine and vasopressin. These results agree with a negative feedback effect of protein kinase C on free Ca oscillations.
摘要
用水母发光蛋白显微注射的单个大鼠肝细胞在用钙动员激素刺激时会出现游离钙振荡。我们在此表明，二酰基甘油激酶抑制剂（R 59 022）和天然二酰基甘油类似物（二C8）可抑制去甲肾上腺素和血管加压素诱导的游离钙振荡。这些结果与蛋白激酶C对游离钙振荡的负反馈作用一致。
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