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[应激对幼鼠肠上皮细胞微绒毛酶系统的影响及应激效应从母鼠传递至子代的可能机制]

[The effect of stress on the enzyme systems of the enterocyte microvilli in rat pups and the possible mechanism of the transmission of stress effects from dam to progeny].

作者信息

Egorova V V, Shinder D A, Rakhimov K R, Ugolev A M

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1992 Jan;78(1):59-66.

PMID:1330718
Abstract

In suckling rats whose mothers had had an immobilisation stress or been injected HC and T4 at the last day of their pregnancy, the sucrase induction decreased in the small intestine, if the HC was injected on the 10th day of life. The hormone injection to 1-day suckling rats did not affect the induction. These effects seem to be exerted not by the direct permeation of hormone from mother to litter but to be mediated rather by a special factor "stressin". The latter is transferred from mother to litter and decreases the sensitivity of intestinal enzymes to exogenous HC, thus exerting an antistressor effect.

摘要

在其母亲在妊娠最后一天遭受固定应激或注射了氢化可的松(HC)和甲状腺素(T4)的乳鼠中,如果在出生后第10天注射HC,小肠中的蔗糖酶诱导作用会降低。给1日龄乳鼠注射激素不会影响诱导作用。这些作用似乎不是通过激素从母体直接渗透到幼崽中发挥的,而是由一种特殊因子“应激素”介导的。后者从母体传递给幼崽,并降低肠道酶对外源性HC的敏感性,从而发挥抗应激作用。

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